It’s come to this: Risk factors protect against risk

Check out this author’s summary:

An elevated triglyceride level is generally considered a risk factor for the development of type-2 diabetes. However, recent studies suggest, somewhat paradoxically, that genetic risk for elevated triglycerides may protect against type-2 diabetes.

Our findings across studies, racial groups, and statistical models consistently demonstrate that triglyceride-increasing alleles are associated with decreased type-2 diabetes incidence. These genes therefore appear to both increase triglyceride levels and decrease type-2 diabetes risk. More work is needed (ed. note but of course) to understand the physiological mechanism underlying these findings, and to determine the causal relationship between triglycerides and type-2 diabetes.


3 responses to “It’s come to this: Risk factors protect against risk

  1. Came across this a few years ago:
    “Glycogen storage disease type Ia (GSD-Ia) is characterized by hypercholesterolemia, hypertriglyceridemia, decreased cholesterol in high density lipoprotein and increased cholesterol in low and very low density lipoprotein fractions.”
    The blog author goes on to say this:
    “Of course, with lipids like those, you should die of CVD at a very early age. But you don’t.”
    “Guess what. People with glycogen storage disease type Ia are virtually never hyperglycaemic or hyperinsulinaemic. In fact hypoglycaemia can be a serious problem for them. But they don’t get heart disease. Funny that.”

    Makes me wonder if some of the people in the current study might have GSD. Most people don’t go through genetic testing because of high cholesterol, therefore unlikely that they would be diagnosed as having GSD.

  2. ernestncurtis

    Of course, there is no causal relationship between elevated triglyceride levels and the hyperglycemia nof the made-up disease known as type II diabetes. This appears to be a data dredge from three cohort studies (read: epidemiology) and therefore signifies precisely nothing. And, yes, these so called risk factors aren’t risky at all.

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